Keywords: Autoimmune (immune), TNF-a, IL-1, IL-6, IL-8 and indirectly – IFNg
Maqola muallifi haqida
* Achilova Donohon Nutfilloevna Shukurov Bakhtiyor Kodirovich Bukhara State Medical Institute named after Abu Ali ibn Sino, Uzbekistan Bukhara city polyclinic No. 6 dermatovenerologist. Uzbekistan
* Autoimmune (immune) theory, proposed in 1959 by A.Lorincz (Lorincz A.I., 1959), who found autosensitization to their own melanocytes and tyrosinase in patients with vitiligo. At present time the idea of vitiligo as an autoimmune disease is based based on a few basic facts. Vitiligo may show skin-infiltrating cytotoxic T-lymphocytes close proximity to melanocytes (Wijngaard R., 2000), as well as antibodies against melanocytic antigens (Bystrun J.C., 1989), which is direct confirmation of the existence of an autoimmune response. ABOUT the involvement of the immune system in the pathogenesis of vitiligo speaks and changes balance of cytokines that regulate the functions of cells of the immune system.
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